Alkylating intermediates in nitrosamine metabolism.
نویسندگان
چکیده
Baird, W. M.,Dipple, A.,Grover,P. L.,Sims,P. &Brookes,P. (1973) Cancer Res. 33,2386-2392 Booth, J. & Sims, P. (1974~) Biochem. Pharmacol. 23,2547-2555 Booth, J. & Sims, P. (1974b) FEBS Lett. 47,30-33 Booth, J., Keysell, G. R. & Sims, P. (1973) Biochem. Pharmacol. 22,1781-1791 Booth, J., Keysell, G. R., Pal, K. & Sims, P. (1974) FEBS Lett. 43,341-344 Boyland, E. (1950) Biochem. SOC. Symp. 5,4044 Grover, P. L. (1974) Biochem. Pharmacol. 23,333-343 Grover, P. L. & Sims, P. (1970) Biochem. Pharmacol. 19,2251-2259 Grover, P. L. & Sims, P. (1973) Biochem. Pharmacol. 22,661-666 Grover, P. L., Forrester, J. A. & Sims, P. (1971a) Biochem. Pharmacol. 20,1297-1302 Grover, P. L., Hewer, A. & Sims, P. (1971b) FEBS Lett. 18,7680 Grover, P. L., Hewer, A. & Sims, P. (1972) Biochem. Pharmacol. 21,2713-2726 Grover, P. L., Hewer, A. & Sims, P. (1973) FEBS Lett. 34,63-68 Keysell, G. R., Booth, J., Grover, P. L., Hewer, A. & Sims, P. (1973) Biochem. Pharmacol. 22,
منابع مشابه
Use of 3,4-Dichlorobenzenethiol as a Trapping Agent for Alkylating Intermediates during in Vitro Metabolism of Nitrosamines1
Our studies using 3,4-dichlorobenzenethiol as a probe for methylating agent production during exposure of /v-nitrosodimethylamine to rat liver S-9 preparations produced results dif ferent from those of an investigation reported in the literature. Methyl-3,4-dichlorophenyl thioether was detected, but the quan tities found were not significantly different from the background levels of methylation...
متن کاملUse of 3,4-dichlorobenzenethiol as a trapping agent for alkylating intermediates during in vitro metabolism of nitrosamines.
Our studies using 3,4-dichlorobenzenethiol as a probe for methylating agent production during exposure of N-nitrosodimethylamine to rat liver S-9 preparations produced results different from those of an investigation reported in the literature. Methyl-3,4-dichlorophenyl thioether was detected, but the quantities found were not significantly different from the background levels of methylation pr...
متن کاملNovel Cationic Dye Based on Naphthalimide: Part 1: Synthesis, Characterization and Evaluation of Biology Efficacy as Antimicrobial Agent
In this paper, synthesis and antimicrobial properties of cationic dye were investigated. 4-acetylamino-N-2-aminomethylpyridine-1,8-naphthalimide was reacted with 1-bromobutane as the alkylating agent and a cationic dye was obtained. The final product was purified by column chromatography method. The chemical structure of the novel cationic dye and its intermediates was chracterisized by using F...
متن کاملMetabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes.
Previous studies have shown that the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is hepatocarcinogenic and results in alkylation of hepatic DNA in F344 rats. In this study, we have characterized the metabolism of NNK in cultured rat hepatocytes and have established the relationship between various metabolic pathways and the induction of DNA single strand ...
متن کاملDe minimus non curat lex--virtual thresholds for cancer initiation by tobacco specific nitrosamines--prospects for harm reduction by smokeless tobacco.
Whereas the impact of tobacco specific nitrosamines in smokers is obscured by the presence of numerous other carcinogens and promoters, for smokeless tobacco virtually all the carcinogenic potential is associated with 4-(nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). In some countries exposure to smokeless tobacco with extremely high nitrosamine concentratio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 3 1 شماره
صفحات -
تاریخ انتشار 1975